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The integration of NSC-derived and host neural networks after rat spinal cord transection

Paper ID Volume ID Publish Year Pages File Format Full-Text
6254 471 2013 14 PDF Available
Title
The integration of NSC-derived and host neural networks after rat spinal cord transection
Abstract

Rebuilding structures that can bridge the injury gap and enable signal connection remains a challenging issue in spinal cord injury. We sought to determine if genetically enhanced expression of TrkC in neural stem cells (NSCs) and neurotrophin-3 in Schwann cells (SCs) co-cultured in a gelatin sponge scaffold could constitute a neural network, and whether it could act as a relay to rebuilt signal connection after spinal cord transection. Indeed, many NSCs in the scaffold assumed neuronal features including formation of synapses. By whole-cell patch clamp, the synapses associated with NSC-derived neurons were excitable. Grafting of the scaffold with differentiating NSCs + SCs into rats with a segment of the spinal cord removed had resulted in a significant functional recovery of the paralyzed hind-limbs. Remarkably, the NSC-derived neurons formed new synaptic contacts suggesting that the scaffold can form a relay for conduction of signals through the injury gap of spinal cord.

Keywords
Neural stem cells; Three-dimensional gelatin sponge scaffolds; Neurotrophin-3; TrkC; Neural network; Spinal cord injury
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 12, April 2013, Pages 2888–2901
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
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