fulltext.study @t Gmail

Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation

Paper ID Volume ID Publish Year Pages File Format Full-Text
6279 471 2013 9 PDF Available
Title
Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation
Abstract

Mesoporous silica-encapsulated gold nanorods (GNRs@mSiO2) have great potential both in photothermal therapy and drug delivery. In this paper, we firstly developed GNRs@mSiO2 as a synergistic therapy tool for delivery heat and drug to the tumorigenic region. We studied the ablation of tumor both in vitro and in vivo by the combination of photothermal therapy and chemotherapy using doxorubicin (DOX)-loaded GNRs@mSiO2. Significantly greater cell killing was observed when A549 cells incubated with DOX-loaded GNRs@mSiO2 were irradiated with near-infrared (NIR) illumination, attributable to both GNRs@mSiO2-mediated photothermal ablation and cytotoxicity of light-triggered DOX release. We then performed in vivo therapy studies and observed a promising tumor treatment. Compared with chemotherapy or photothermal treatment alone, the combined treatment showed a synergistic effect, resulting in higher therapeutic efficacy. Furthermore, the lower systematic toxicity of GNRs@mSiO2 has been validated.

Keywords
Mesoporous silica-encapsulated gold nanorods; Photothermal therapy; Chemotherapy; Synergistic effect
First Page Preview
Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 12, April 2013, Pages 3150–3158
Authors
, , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us