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Platinum nanoparticles for the photothermal treatment of Neuro 2A cancer cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
6319 480 2013 10 PDF Available
Title
Platinum nanoparticles for the photothermal treatment of Neuro 2A cancer cells
Abstract

This study demonstrates the effective synthesis of five different sized/shaped Pt NPs, within a narrow size regime of 1–21 nm using a modified methodology and the toxicity/biocompatibility of Pt NPs on Neuro 2A cancer cells was investigated elaborately by using light microscopic observations, tryphan blue exclusion assay, MTT assay and ICP-MS. The Pt NPs-C with sizes 5–6 nm showed superior non-cytotoxic property compared to the other four Pt NPs. These non-cytotoxic Pt NPs were employed for successful photothermal treatment of Neuro 2A cell lines using near-IR 1064 nm of laser irradiation. The Pt NPs-C could generate a 9 °C increase in temperature leading to effective photothermal killing of cancer cells. The MALDI-MS was used to prove the possibility of apoptosis related triggering of cell death in the presence of the Pt NPs. The results confirm that the current approach is an effective platform for in vivo treatment of neuro cancer cells.

Keywords
Neuro 2A cancer cells; Pt NPs; Photothermal treatment; Compatibility; Toxicity
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Platinum nanoparticles for the photothermal treatment of Neuro 2A cancer cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 23, July 2013, Pages 5833–5842
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us