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Multimodal contrast agents for in vivo neuroanatomical analysis of monosynaptic connections

Paper ID Volume ID Publish Year Pages File Format Full-Text
6336 484 2013 8 PDF Available
Title
Multimodal contrast agents for in vivo neuroanatomical analysis of monosynaptic connections
Abstract

We developed and examined the applicability of two multimodal paramagnetic contrast agents for the longitudinal in vivo investigations of the brain projections. The classical dextran based neuroanatomical tracer was conjugated with mono- and bimetal Gd3+ complexes and an optical reporter. Relaxometric studies of both tracer molecules were performed in vitro followed by in cellulo MR and microscopy investigations. Finally, tracers were injected into the motor cortex of the rat brain; uptake and transporting properties were compared by MRI. The advantage of the multimodal approach was taken and histological studies were performed on the same animals. The histology results confirm the MRI studies demonstrating that the applied tracers labelled anterogradely the regions known for their connections with the motor cortex of the rat brain.

Keywords
MRI contrast agent; Gadolinium; Brain connectivity; Tracers; Dextran; Neural network
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Multimodal contrast agents for in vivo neuroanatomical analysis of monosynaptic connections
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 29, September 2013, Pages 7135–7142
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us