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The role of microscaffold properties in controlling the collagen assembly in 3D dermis equivalent using modular tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
6377 488 2013 11 PDF Available
Title
The role of microscaffold properties in controlling the collagen assembly in 3D dermis equivalent using modular tissue engineering
Abstract

The realization of thick and viable tissues equivalents in vitro is one of the mayor challenges in tissue engineering, in particular for their potential use in tissue-on-chip technology. In the present study we succeeded in creating 3D viable dermis equivalent tissue, via a bottom-up method, and proved that the final properties, in terms of collagen assembly and organization of the 3D tissue, are tunable and controllable by micro-scaffold properties and degradation rate. Gelatin porous microscaffolds with controlled stiffness and degradation rate were realized by changing the crosslinking density through different concentrations of glyceraldehyde. Results showed that by modulating the crosslinking density of the gelatin microscaffolds it is possible to guide the process of collagen deposition and assembly within the extracellular space and match the processes of scaffold degradation, cell traction and tissue maturation to obtain firmer collagen network able to withstand the effect of contraction.

Keywords
Dermis; Collagen assembly; TOC; Gelatin microscaffold; SHG; Modular tissue engineering
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The role of microscaffold properties in controlling the collagen assembly in 3D dermis equivalent using modular tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 32, October 2013, Pages 7851–7861
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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