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In situ forming acyl-capped PCLA–PEG–PCLA triblock copolymer based hydrogels

Paper ID Volume ID Publish Year Pages File Format Full-Text
6391 488 2013 10 PDF Available
Title
In situ forming acyl-capped PCLA–PEG–PCLA triblock copolymer based hydrogels
Abstract

Sustained intra-articular drug delivery opens up new opportunities for targeted treatment of osteoarthritis. In this study, we investigated the in vitro and in vivo properties and performance of a newly developed hydrogel based on acyl-capped PCLA–PEG–PCLA specifically designed for intra-articular use. The hydrogel formulation consisted of a blend of polymers either capped with acetyl, or with 2-(2′,3′,5′,-triiodobenzoyl, TIB) moieties. TIB was added to visualize the gel using μCT, enabling longitudinal quantification of its degradation. Blends containing TIB-capped polymer degraded in vitro (37 °C; pH 7.4 buffer) through dissolution over a period of ∼20 weeks, and degraded slightly faster (∼12 weeks) after subcutaneous injection in rats. This in vivo acceleration was likely due to active (enzymatic) degradation, shown by changes in polymer composition and molecular weight as well as the presence of macrophages. After intra-articular administration in rats, the visualized gel gradually lost signal intensity over the course of 4 weeks. Good cytocompatibility of acetyl-capped polymer based hydrogel was proven in vitro on erythrocytes and chondrocytes. Moreover, intra-articular biocompatibility was demonstrated using μCT-imaging and histology, since both techniques showed no changes in cartilage quality and/or quantity.

Keywords
Biocompatibility; Hydrogel; Drug delivery system; Radiopaque; PCLA–PEG–PCLA; Intra-articular
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In situ forming acyl-capped PCLA–PEG–PCLA triblock copolymer based hydrogels
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 32, October 2013, Pages 8002–8011
Authors
, , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us