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A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

Paper ID Volume ID Publish Year Pages File Format Full-Text
6405 489 2013 27 PDF Available
Title
A review of nanotechnological approaches for the prophylaxis of HIV/AIDS
Abstract

Successful treatment and control of HIV/AIDS is one of the biggest challenges of 21st century. More than 33 million individuals are infected with HIV worldwide and more than 2 million new cases of HIV infection have been reported. The situation demands development of effective prevention strategies to control the pandemic of AIDS. Due to lack of availability of an effective HIV vaccine, antiretroviral drugs and nucleic acid therapeutics like siRNA have been explored for HIV prophylaxis. Clinical trials shave shown that antiretroviral drugs, tenofovir and emtricitabine can offer some degree of HIV prevention. However, complete prevention of HIV infection has not been achieved yet. Nanotechnology has brought a paradigm shift in the diagnosis, treatment and prevention of many diseases. The current review discusses potential of various nanocarriers such as dendrimers, polymeric nanoparticles, liposomes, lipid nanocarriers, drug nanocrystals, inorganic nanocarriers and nanofibers in improving efficacy of various modalities available for HIV prophylaxis.

Keywords
HIV; Nanotechnology; Polymeric nanoparticles; Dendrimers; Prophylaxis; Vaginal delivery
First Page Preview
A review of nanotechnological approaches for the prophylaxis of HIV/AIDS
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 26, August 2013, Pages 6202–6228
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering