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Photostable water-dispersible NIR-emitting CdTe/CdS/ZnS core–shell–shell quantum dots for high-resolution tumor targeting

Paper ID Volume ID Publish Year Pages File Format Full-Text
6460 491 2013 10 PDF Available
Title
Photostable water-dispersible NIR-emitting CdTe/CdS/ZnS core–shell–shell quantum dots for high-resolution tumor targeting
Abstract

Near-infrared (NIR, 700–900 nm) fluorescent quantum dots are highly promising as NIR bioprobes for high-resolution and high-sensitivity bioimaging applications. In this article, we present a class of NIR-emitting CdTe/CdS/ZnS core–shell–shell quantum dots (QDs), which are directly prepared in aqueous phase via a facile microwave synthesis. Significantly, the prepared NIR-emitting QDs possess excellent aqueous dispersibility, strong photoluminescence, favorable biocompatibility, robust storage-, chemical-, and photo-stability, and finely tunable emission in the NIR range (700–800 nm). The QDs are readily functionalized with antibodies for use in immunofluorescent bioimaging, yielding highly spectrally and spatially resolved emission for in vitro and in vivo imaging. In comparison to the large size of 15–30 nm of the conventional NIR QDs, the extremely small size (∼4.2 nm or 7.5 nm measured by TEM or DLS, respectively) of our QDs offers great opportunities for high-efficiency and high-sensitivity targeted imaging in cells and animals.

Keywords
Near infrared; Quantum dots; Core–shell–shell; In vitro and in vivo; Bioimaging
First Page Preview
Photostable water-dispersible NIR-emitting CdTe/CdS/ZnS core–shell–shell quantum dots for high-resolution tumor targeting
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 37, December 2013, Pages 9509–9518
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering