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The effect of octadecyl chain immobilization on the hemocompatibility of poly (2-hydroxyethyl methacrylate)

Paper ID Volume ID Publish Year Pages File Format Full-Text
6485 492 2012 9 PDF Available
Title
The effect of octadecyl chain immobilization on the hemocompatibility of poly (2-hydroxyethyl methacrylate)
Abstract

Albumin-scavenging surfaces decorated with n-alkyl chains represent an established strategy for blood-contacting applications. To evaluate this concept, a set of poly (2-hydroxyethyl methacrylate) (pHEMA) films modified with different amounts of octadecyl isocyanate (C18) was investigated in an in vitro hemocompatibility assay using freshly drawn human whole blood. In addition, the hydrogel materials were thoroughly characterized with respect to changes in wettability and elasticity, which accompanied the gradual chemical modification of pHEMA. An increase of the surface C18 content induced enhanced hydrophobicity and stiffness. Immobilization of C18 chains was found to substantially reduce the coagulation activation and the complement activation by the pHEMA films. Platelet adhesion and degranulation (PF4 release) were similar on the modified and the unmodified pHEMA. Platelet adhesion to pHEMA hydrogels was lower than the polytetrafluoroethylene reference. We conclude that the immobilization of octadecyl chains improved the hemocompatibility of pHEMA materials under conditions that might be encountered in low shear blood flow.

Keywords
PolyHEMA; Albumin; Protein adsorption; Haemocompatibility; Platelets; Biomaterials
First Page Preview
The effect of octadecyl chain immobilization on the hemocompatibility of poly (2-hydroxyethyl methacrylate)
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 31, November 2012, Pages 7677–7685
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering