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Hyperbranched polydiselenide as a self assembling broad spectrum anticancer agent

Paper ID Volume ID Publish Year Pages File Format Full-Text
6494 492 2012 10 PDF Available
Title
Hyperbranched polydiselenide as a self assembling broad spectrum anticancer agent
Abstract

This work presents a highly efficient, broad spectrum and self-delivery anticancer agent, which is the hyperbranched polydiselenide (HPSe) consisting of alternative hydrophobic diselenide groups and hydrophilic phosphate segments in the backbone framework. The data of systematic evaluations demonstrate that HPSe is very potent to inhibit the proliferation of many forms of cancer cell. The dose of HPSe required for growth inhibition of 50% (IC50) in all of the tested cancer cell lines is within the concentration range between 1 and 2.5 μg mL−1 with the incubation time of 72 h. Furthermore, the amphiphilic HPSe can self-assembly into nanomicelles with an average diameter of 50 nm and spontaneously enter into tumor cells by the enhanced permeability and retention (EPR) effect. Besides, other hydrophobic anticancer drugs such as doxorubicin (DOX) can be encapsulated into HPSe micelles for combining therapy.

Keywords
Polydiselenide; Hyperbranched; Anticancer agent; Self-delivery; Broad spectrum
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 31, November 2012, Pages 7765–7774
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us