fulltext.study @t Gmail

Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields

Paper ID Volume ID Publish Year Pages File Format Full-Text
6555 500 2013 8 PDF Available
Title
Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields
Abstract

The efficacy of nanoparticle-mediated drug delivery is limited by its peri-vascular sequestration, thus necessitating a strategy to trigger drug release from such intra-tumoral nanocarrier-drug depots. In our efforts to explore remotely-activated nanocarriers, we have developed carbon nanocapsules comprised of an ultra-short carbon nanotube shell (US-tubes) loaded with cisplatin (CDDP@US-tubes) and covered with a Pluronic surfactant wrapping to minimize passive release. We demonstrate here that non-invasive radiofrequency (RF) field activation of the CDDP@US-tubes produces heat that causes Pluronic disruption which triggers cisplatin release in an RF-dependent manner. Furthermore, release-dependent cytotoxicity is demonstrated in human hepatocellular carcinoma cell lines.

Keywords
Radiofrequency field; Carbon nanotubes; US-tubes; Triggered release; Liver cancer; Cisplatin
First Page Preview
Remotely triggered cisplatin release from carbon nanocapsules by radiofrequency fields
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 7, February 2013, Pages 1862–1869
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering