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Bright blue emitting CuSe/ZnS/silica core/shell/shell quantum dots and their biocompatibility

Paper ID Volume ID Publish Year Pages File Format Full-Text
6568 501 2012 10 PDF Available
Title
Bright blue emitting CuSe/ZnS/silica core/shell/shell quantum dots and their biocompatibility
Abstract

In the in vivo scenario, the nanomaterials have to stay for a prolonged period in fluids like blood and therefore a detailed understanding of their interaction with blood elements is mandatory. We report the synthesis and characterization of highly blue emitting smaller size, 3.6 nm CuSe quantum dots (QDs) and its core/shell structure CuSe/ZnS. We modified QDs with a silica shell, which is the most accepted approach to lessen the toxic liabilities, and the blood compatibility of resultant CuSe/ZnS/Silica QDs were evaluated. MTT assay and cellular uptake using HepG2 and C 6 glioma cancer cells were studied to show their potential as drug targeting vehicles. The documented observation to date about the silica on cells is its ability to cause apoptosis by the production of reactive oxygen species. However, its impact on the blood cells has never been addressed or studied in detail. Our data indicate that concentrations of ≤50 μg/mL CuSe/ZnS/Silica QDs are blood compatible. The concentration dependant blood compatibility of silica modified QDs, point out the need for rethinking of using silica coatings over nanomaterials for diverse applications like drug targeting and cellular labeling.

Keywords
Quantum dots; Blue emission; Silica shell; Blood compatibility; Cancer cell targeting
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 27, September 2012, Pages 6420–6429
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us