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Physiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
6660 510 2012 7 PDF Available
Title
Physiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles
Abstract

We disclosed a specific biological pathway for the observed cell damage when stimulated by the crystalline SiO2 nanoparticles (NPs), i.e., both mitochondrion multiplication and DNA fragmentation occur upon the initial reactive oxygen species (ROS) generation, with the former causing further increases of the ROS level in the cell, and eventually leads to catastrophic effect on cell physiology. Such damage becomes nontrivial only in the absence of p53 gene, which regulates cells' anti-oxidation and detoxification. This genotoxic effect is absent in cells treated with amorphous SiO2 NPs.

Keywords
Silica nanoparticles; ROS generation; Mitochondrion multiplication; DNA damage; p53
First Page Preview
Physiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 30, October 2012, Pages 7540–7546
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering