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Hippocampal cell response to substrates with surface chemistry gradients

Paper ID Volume ID Publish Year Pages File Format Full-Text
668 57 2011 11 PDF Available
Title
Hippocampal cell response to substrates with surface chemistry gradients
Abstract

Surface chemical gradients are valuable tools for the high-throughput screening of cell–surface interactions. However, it has yet to be shown if biological data obtained from gradient surfaces are transferable to substrates with uniform properties. To explore this question, the response of hippocampal neurons to three different sample formats was compared. We fabricated samples of uniform surface wettability and samples with a linear or radial gradient in surface wettability by depositing plasma-polymerized hexane (hydrophobic) on oxygen-etched glass (hydrophilic). Differences in cell density, growth and viability of the neural cultures are found between the uniform and the gradient samples. The nature of the gradient (linear or radial) has only a small effect on the cell density of adhered hippocampal neurons.

Keywords
Neurons; Cell–surface interactions; Surface modification; Chemical gradients
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 12, December 2011, Pages 4120–4130
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us