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Spatially controlled carbon sponge for targeting internalized radioactive materials in human body

Paper ID Volume ID Publish Year Pages File Format Full-Text
6682 511 2012 11 PDF Available
Title
Spatially controlled carbon sponge for targeting internalized radioactive materials in human body
Abstract

Carbon sponge, an adsorbent with spatially controlled structure is demonstrated for targeting internalized radiocesium and other radionuclides in human body. Three dimensionally ordered macroporous (3DOM) carbons derived from inverse opal replicas of colloidal-crystal template exhibit large surface area and high porosity, resulting in highly efficient adsorbents for radionuclides. It is also possible to enhance binding affinity and selectivity to radionuclide targets by decoration of 3DOM carbon surfaces with Prussian blue (PB) nanoparticles, and synthesized PB nanoparticles reveal low toxicity toward macrophage cells with potential advantages over oral administration. It is noteworthy that the maximum 133Cs adsorption capacity of PB-decorated 3DOM carbons is 40.07 mmol g−1 which is ca. 30 and 200 times higher than that of commercialized medicine Radiogardase® and bulk PB, respectively. Further, adsorption kinetics study indicates that the PB-decorated 3DOM carbons have the homogenous surface for 133Cs ion adsorption and all sites have equal adsorption energies in terms of ion exchange between the cyano groups of the PB-decorated 3DOM carbons and radionuclides. As a concept of the oral-administrable “carbon sponge”, the PB-decorated 3DOM carbons offer useful implications in the separation science of radioactive materials and important insight for designing novel materials for treatment of patients or suspected internal contamination with radioactive materials.

Keywords
Biocompatibility; Cytotoxicity; Drug delivery; Microstructure; Porosity; Surface modification
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Spatially controlled carbon sponge for targeting internalized radioactive materials in human body
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 20, July 2012, Pages 5056–5066
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us