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Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
6683 511 2012 9 PDF Available
Title
Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering
Abstract

Multifunctional bone scaffold materials have been produced from a biodegradable polymer, poly(l-lactic acid) (PLLA), and 1–10% wt of octadecylamine-functionalized nanodiamond (ND-ODA) via solution casting followed by compression molding. By comparison to pure PLLA, the addition of 10% wt of ND-ODA resulted in a significant improvement of the mechanical properties of the composite matrix, including a 280% increase in the strain at failure and a 310% increase in fracture energy in tensile tests. The biomimetic process of bonelike apatite growth on the ND-ODA/PLLA scaffolds was studied using microscopic and spectroscopic techniques. The enhanced mechanical properties and the increased mineralization capability with higher ND-ODA concentration suggest that these biodegradable composites may potentially be useful for a variety of biomedical applications, including scaffolds for orthopedic regenerative engineering.

Keywords
Nanodiamond; Nanocomposite; Mechanical properties; Biomineralization; Bone tissue engineering
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Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 20, July 2012, Pages 5067–5075
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us