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Investigation of ethanol infiltration into demineralized dentin collagen fibrils using molecular dynamics simulations

Paper ID Volume ID Publish Year Pages File Format Full-Text
67 5 2016 11 PDF Available
Title
Investigation of ethanol infiltration into demineralized dentin collagen fibrils using molecular dynamics simulations
Abstract

•Using molecular simulation, ethanol infiltration into the collagen was investigated.•Ethanol molecules infiltrated into the gap region only.•Only the third bound water layer was modified by ethanol molecules.

The purpose of this study is to investigate the interaction of neat ethanol with bound and non-bound water in completely demineralized dentin that is fully hydrated, using molecular dynamics (MD) simulation method. The key to creating ideal resin-dentin bonds is the removal of residual free water layers and its replacement by ethanol solvent in which resin monomers are soluble, using the ethanol wet-bonding technique. The test null hypotheses were that ethanol cannot remove any collagen-bound water, and that ethanol cannot infiltrate into the spacing between collagen triple helix due to narrow interlayer spacing. Collagen fibrillar structures of overlap and gap regions were constructed by aligning the collagen triple helix of infinite length in hexagonal packing. Three layers of the water molecules were specified as the layers of 0.15–0.22 nm, 0.22–0.43 nm and 0.43–0.63 nm from collagen atoms by investigating the water distribution surrounding collagen molecules. Our simulation results show that ethanol molecules infiltrated into the intermolecular spacing in the gap region, which increased due to the lateral shrinkage of the collagen structures in contact with ethanol solution, while there was no ethanol infiltration observed in the overlap region. Infiltrated ethanol molecules in the gap region removed residual water molecules via modifying mostly the third water layer (50% decrease), which would be considered as a loosely-bound water layer. The first and second hydration layers, which would be considered as tightly bound water layers, were not removed by the ethanol molecules, thus maintaining the helical structures of the collagen molecules.

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Keywords
Dentin matrix; Bound water; Collagen; Gap regions; Ethanol; Molecular dynamics simulation
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Investigation of ethanol infiltration into demineralized dentin collagen fibrils using molecular dynamics simulations
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 36, May 2016, Pages 175–185
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us