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Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline) hydrogels

Paper ID Volume ID Publish Year Pages File Format Full-Text
671 57 2011 11 PDF Available
Title
Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline) hydrogels
Abstract

A novel thermoreversible hydrogel based on poly(2-ethyl-2-oxazoline)-derived amphiphilic triblock copolymer, poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline) (PEOz–PLA–PEOz), was developed. The synthesis of PEOz–PLA–PEOz was carried out by coupling monohydroxylated PEOz–PLA diblocks with adipoyl chloride as coupling agent and dimethylamino pyridine as catalyst. The tube inverting and rheological tests showed that triblock copolymers had sol–gel–sol transition behavior with increasing temperature, and the gelation was found to be thermoreversible. The critical gelation concentration, the sol–gel transition temperature at a given concentration depended on the EOz/LA ratio and the molecular weight of PEOz. Scanning electron microscopy observation revealed that the resultant bulky gel exhibited an interconnected porous three-dimensional (3D) microstructure after freeze-drying. In addition, the hydrogels showed good cytocompatibility in vitro. MTT assays revealed that the human skin fibroblast cells encapsulated within the hydrogels were viable and proliferated inside the 3D scaffold. This newly described thermoreversible hydrogel demonstrated attractive properties to serve as cell matrix for a variety of tissue engineering applications or pharmaceutical delivery vehicles.

Keywords
Thermosensitive hydrogel; Human skin fibroblast cells; Biocompatibility; Poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline); Scaffold
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Synthesis, characterization and biocompatibility of poly(2-ethyl-2-oxazoline)–poly(d,l-lactide)–poly(2-ethyl-2-oxazoline) hydrogels
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 12, December 2011, Pages 4149–4159
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us