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TAT-modified nanosilver for combating multidrug-resistant cancer

Paper ID Volume ID Publish Year Pages File Format Full-Text
6715 513 2012 7 PDF Available
TAT-modified nanosilver for combating multidrug-resistant cancer

A nanopharmaceutical system using TAT-enhanced cell/tissue penetration strategy was developed for multidrug-resistant (MDR) cancer treatment, in which nanocrystalline silver with mean size of 8 nm modified with TAT cell-penetrating peptide (termed AgNP-TAT) displayed extraordinary antitumor activity in both MDR cells and non-resistant cells at an indiscriminating manner. Such anti-MDR effect is presumably due to the size-exclusion effect, by which the nanoparticles are too large to be pumped out. Of note, AgNP-TAT showed significant enhancement in killing tumor cells, e.g. up to 24 fold higher compared to its counterpart without TAT-modification. The animal studies further confirmed the success of our strategy that AgNP-TAT was able to effectively inhibit the tumor growth in the mice bearing malignant melanoma at a dose of 1 nmol/kg, compared with the effective dose (4.3 μmol/kg) of doxorubicin. AgNP-TAT also showed significantly reduced adverse toxicity in vivo. It indicates AgNP-TAT could be a class of nano drug for MDR cancer treatment.

Silver nanoparticle; Cell-penetrating peptide; Multidrug resistance; Cancer; TAT
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TAT-modified nanosilver for combating multidrug-resistant cancer
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 26, September 2012, Pages 6155–6161
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Physical Sciences and Engineering Chemical Engineering Bioengineering