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Water-stable NaLuF4-based upconversion nanophosphors with long-term validity for multimodal lymphatic imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
6720 513 2012 10 PDF Available
Title
Water-stable NaLuF4-based upconversion nanophosphors with long-term validity for multimodal lymphatic imaging
Abstract

Multimodal imaging is rapidly becoming an important tool for biomedical applications because it can compensate for the deficiencies of individual imaging modalities. Herein, multifunctional NaLuF4-based upconversion nanoparticles (Lu-UCNPs) were synthesized though a facile one-step microemulsion method under ambient condition. The doping of lanthanide ions (Gd3+, Yb3+ and Er3+/Tm3+) endows the Lu-UCNPs with high T1-enhancement, bright upconversion luminescence (UCL) emissions, and excellent X-ray absorption coefficient. Moreover, the as-prepared Lu-UCNPs are stable in water for more than six months, due to the protection of sodium glutamate and diethylene triamine pentacetate acid (DTPA) coordinating ligands on the surface. Lu-UCNPs have been successfully applied to the trimodal CT/MR/UCL lymphatic imaging on the modal of small animals. It is worth noting that Lu-UCNPs could be used for imaging even after preserving for over six months. In vitro transmission electron microscope (TEM), methyl thiazolyl tetrazolium (MTT) assay and histological analysis demonstrated that Lu-UCNPs exhibited low toxicity on living systems. Therefore, Lu-UCNPs could be multimodal agents for CT/MR/UCL imaging, and the concept can be served as a platform technology for the next-generation of probes for multimodal imaging.

Keywords
Lanthanide; Upconversion nanoparticles; Upconversion luminescence imaging; Multimodal imaging; Water-stable
First Page Preview
Water-stable NaLuF4-based upconversion nanophosphors with long-term validity for multimodal lymphatic imaging
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 26, September 2012, Pages 6201–6210
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering