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The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold

Paper ID Volume ID Publish Year Pages File Format Full-Text
6764 516 2012 10 PDF Available
Title
The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold
Abstract

Biologic scaffolds composed of mammalian extracellular matrix (ECM) are routinely used for the repair and reconstruction of injured or missing tissues in a variety of pre-clinical and clinical applications. However, the structural and functional outcomes have varied considerably. An important variable of xenogeneic biologic scaffolds is the age of the animal from which the ECM is derived. The present study compared the in vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in age. Results showed that there are distinct differences in the remodeling characteristics as a consequence of source animal age. Scaffolds derived from younger animals were associated with a more constructive, site appropriate, tissue remodeling response than scaffolds derived from older animals. Furthermore, the constructive remodeling response was associated with a dominant M2 macrophage response.

Keywords
Age/ageing; ECM (extracellular matrix); Scaffold; Macrophage; Immune response; Mechanical properties
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The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 22, August 2012, Pages 5524–5533
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us