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The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
6770 516 2012 9 PDF Available
Title
The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles
Abstract

The present work demonstrates that Cy5.5 conjugated Fe3O4/SiO2 core/shell nanoparticles could allow us to control movement of human natural killer cells (NK-92MI) by an external magnetic field. Required concentration of the nanoparticles for the cell manipulation is as low as ∼20 μg Fe/mL. However, the relative ratio of the nanoparticles loaded NK-92MI cells infiltrated into the target tumor site is enhanced by 17-fold by applying magnetic field and their killing activity is still maintained as same as the NK-92MI cells without the nanoparticles. This approach allows us to open alternative clinical treatment with reduced toxicity of the nanoparticles and enhanced infiltration of immunology to the target site.

Keywords
Fe3O4/SiO2 core/shell nanoparticles; Multifunctional nanoparticles; Magnetic field guided cell control; Natural killer cells; Tumor killing activity
First Page Preview
The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 22, August 2012, Pages 5584–5592
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering