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Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons

Paper ID Volume ID Publish Year Pages File Format Full-Text
6773 516 2012 8 PDF Available
Title
Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons
Abstract

We have developed a straightforward method to prepare 1st and 2nd generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, in vitro. These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications.

Keywords
Dendrons; Adamantane; Ibuprofen; Anti-inflammatory activity; Drug delivery
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Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 22, August 2012, Pages 5610–5617
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us