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Cell response induced by internalized bacterial magnetic nanoparticles under an external static magnetic field

Paper ID Volume ID Publish Year Pages File Format Full-Text
6777 516 2012 8 PDF Available
Title
Cell response induced by internalized bacterial magnetic nanoparticles under an external static magnetic field
Abstract

Magnetic nanoparticles are widely used in bioapplications such as imaging and targeting tool. Their magnetic nature allows for the more efficient bioapplications by an external field gradient. However their combined effects have not yet been extensively characterized. Herein, we first demonstrate the biological effects of the communications between internalized bacterial magnetic nanoparticles (BMPs) and an external static magnetic field (SMF) on a standard human cell line. Combination of the BMPs and SMF act as the key factor leading to the alteration of cell structure and the enhanced cell growth. Also, their interaction reduced the apoptotic efficiency of human tumor cells induced by anticancer drugs. Microarray analysis suggests that these phenomena were caused by the alterations of GPCRs-mediated signal transduction originated in the interaction of internalized BMPs and the external SMF. Our findings may offer new approach for targeted cell therapy with the advantage of controlling cell viability by magnetic stimulation.

Keywords
Bacterial magnetic nanoparticles (BMPs); Magnetic field; Proliferation; Antiapoptosis; Microarray
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Cell response induced by internalized bacterial magnetic nanoparticles under an external static magnetic field
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 22, August 2012, Pages 5650–5657
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us