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A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs

Paper ID Volume ID Publish Year Pages File Format Full-Text
6820 519 2012 11 PDF Available
Title
A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs
Abstract

In the field of tissue engineering and regenerative medicine there is significant unmet need for critically-sized, fully degradable biomaterial scaffold systems with tunable properties for optimizing tissue formation in vitro and tissue regeneration in vivo. To address this need, we have developed a silk-based scaffold platform that has tunable material properties, including localized and bioactive functionalization, degradation rate, and mechanical properties and that provides arrays of linear hollow channels for delivery of oxygen and nutrients throughout the scaffold bulk. The scaffolds can be assembled with dimensions that range from millimeters to centimeters, addressing the need for a critically-sized platform for tissue formation. We demonstrate that the hollow channel arrays support localized and confluent endothelialization. This new platform offers a unique and versatile tool for engineering ‘tailored’ scaffolds for a range of tissue engineering and regenerative medicine needs.

Keywords
Silk; Tissue engineering; Oxygen/nutrient delivery; Vascularization; Porous scaffold; Hollow channels
First Page Preview
A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 36, December 2012, Pages 9214–9224
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering