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PEG modified BaGdF5:Yb/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
6822 519 2012 7 PDF Available
Title
PEG modified BaGdF5:Yb/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging
Abstract

Herein, a multi-functional nanoprobe of polyethylene glycol (PEG) modified BaGdF5:Yb/Er upconversion nanoparticles (UCNPs) for tri-modal bioimaging of fluorescence, computed X-ray tomography (CT), and magnetic application is demonstrated for the first time. The PEG-modified BaGdF5:Yb/Er UCNPs with optimal small size were synthesized by a facile one-pot hydrothermal method. The as-designed single-phase nanoprobe presents near-infrared to visible upconversion emissions in UC fluorescent bioimaging of HeLa cell. Importantly, we have demonstrated in vivo CT images with enhanced signals of spleen of a mouse for 2 h, indicating the UCNPs can be successfully used as CT contrast agent for improving the detection of splenic diseases. In addition, these UCNPs also exhibit excellent intrinsic paramagnetic property which can be also for magnetic imaging. Therefore, our results indicate that a tri-modal nanoprobe served as fluorescent/CT/magnetic bioimaging can be realized using the PEG-modified BaGdF5:Yb/Er UCNPs with very low cytotoxicity and long circulation time, which would be very useful in a variety of biomedical application fields.

Keywords
Upconversion; Nanoparticle; Fluorecent bio-imaging; X-ray computed tomography; Magnetic property
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PEG modified BaGdF5:Yb/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 36, December 2012, Pages 9232–9238
Authors
, , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us