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An epirubicin–conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer

Paper ID Volume ID Publish Year Pages File Format Full-Text
6876 523 2012 12 PDF Available
Title
An epirubicin–conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer
Abstract

Multidrug resistance (MDR) presents a major obstacle to curing cancer. Chemotherapy failure can occur through both cell membrane drug resistance (CMDR) and nuclear drug resistance (NDR), and anticancer effectiveness of chemotherapeutic agents is especially reduced by their nuclear export. Here we report an exciting magnetically-targeted nanomedicine formed by conjugation of epirubicin (EPI) to non-toxic and high-magnetization nanocarrier (HMNC). Strikingly, HMNC-EPI overcomes both CMDR and NDR in human bladder cancer cell models, without using P-glycoprotein (P-gp) and nuclear pore inhibitors. Besides, the half-life of drug is prolonged ∼1.8-fold (from 45 h to 81 h) at 37 °C, with a ∼10-fold increase in concentration at the tumor site through magnetic targeting (MT). Moreover, malignant NDR bladder cancer can be effectively inhibited after 14 days in mice by just two injections and MT. We are the first to demonstrate the nanomedical strategy that can overcome the CMDR and NDR bladder cancers simultaneously, and proceed to the excellent MT therapy, significantly reducing the dosage and cardiotoxicity and holding great promise for incurable human MDR bladder cancer.

Keywords
Bladder cancer; Chemotherapy; Multidrug resistance; Magnetic targeting; MRI
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An epirubicin–conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 15, May 2012, Pages 3919–3930
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us