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Fabrication aspects of PLA-CaP/PLGA-CaP composites for orthopedic applications: A review

Paper ID Volume ID Publish Year Pages File Format Full-Text
688 60 2016 18 PDF Available
Title
Fabrication aspects of PLA-CaP/PLGA-CaP composites for orthopedic applications: A review
Abstract

For several decades, composites made of polylactic acid-calcium phosphates (PLA-CaP) and polylactic acid-co-glycolic acid-calcium phosphates (PLGA-CaP) have seen widespread uses in orthopedic applications. This paper reviews the fabrication aspects of these composites, following the ubiquitous materials science approach by studying “processing–structure–property” correlations. Various fabrication processes such as microencapsulation, phase separation, electrospinning, supercritical gas foaming, etc., are reviewed, with specific examples of their applications in fabricating these composites. The effect of the incorporation of CaP materials on the mechanical and biological performance of PLA/PLGA is addressed. In addition, this paper describes the state of the art on challenges and innovations concerning CaP dispersion, incorporation of biomolecules/stem cells and long-term degradation of the composites.

Keywords
PLA; PLGA; CaP; Composite; Fabrication
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Fabrication aspects of PLA-CaP/PLGA-CaP composites for orthopedic applications: A review
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 6, July 2012, Pages 1999–2016
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us