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The inhibition of Th17 immune response in vitro and in vivo by the carbosilane dendrimer 2G-NN16

Paper ID Volume ID Publish Year Pages File Format Full-Text
6884 523 2012 8 PDF Available
Title
The inhibition of Th17 immune response in vitro and in vivo by the carbosilane dendrimer 2G-NN16
Abstract

We evaluated the 2G-NN16-carbosilane dendrimer activities in Th17 response as a potential therapy for Th17 deregulated pathologies. IL17A, IL17F, IL22, IL23 and other interleukins secreted by Th17 cells CD4+ cells were down regulated when cells were cultured in the presence of this dendrimer. Furthermore, IL17F and IL17A protein levels in splenocytes from mice pretreated with 2G-NN16 dendrimer in a Th17 induction mouse model were lower than those corresponding to PBS treated mice. Treatment of mice with 2G-NN16 inhibited the Th17 response causing much more pathogenicity as indicated by the increase in the number of Candida albicans colonies in the kidneys as compared to PBS-treated mice. All these results suggest a potential pharmacological application for this dendrimer in the therapy of Th17-mediated diseases.

Keywords
Th17; Carbosilane dendrimer; Th17 mouse model; IL17F; IL17A2G-NN16, second generation ammonium-terminated carbosilane dendrimer
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The inhibition of Th17 immune response in vitro and in vivo by the carbosilane dendrimer 2G-NN16
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 15, May 2012, Pages 4002–4009
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us