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Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
689 60 2017 17 PDF Available
Title
Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery
Abstract

Self-assembly of amphiphilic block co-polymers composed of poly(ethylene oxide) (PEO) as the hydrophilic block and poly(ether)s, poly(amino acid)s, poly(ester)s and polypropyleneoxide (PPO) as the hydrophobic block can lead to the formation of nanoscopic structures of different morphologies. These structures have been the subject of extensive research in the past decade as artificial mimics of lipoproteins and viral vectors for drug and gene delivery. The aim of this review is to provide an overview of the synthesis of commonly used amphiphilic block co-polymers. It will also briefly go over some pharmaceutical applications of amphiphilic block co-polymers as “nanodelivery systems” for small molecules and gene therapeutics.

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Keywords
Drug delivery; Nanotechnology; Polymeric micelles; Block co-polymers; Drug targeting
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Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 6, July 2012, Pages 2017–2033
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us