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Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
6912 524 2012 16 PDF Available
Title
Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy
Abstract

Gold nanoclusters (NCs) were functionalized as a fluorescent probe and a pro-drug intended for tumor diagnosis and therapy. Firstly, Au NCs were conjugated with methionine (Met) and MPA, a near-infrared (NIR) fluorescent dye, giving a probe, Au-Met-MPA. The tumor targeting capability endowed by Met as well as low cytotoxicity of this contrast agent and its clinical potential for tumor targeting imaging were demonstrated in vitro and in vivo. Secondly, Doxorubicin (DOX), a widely used clinical anti-cancer drug, was immobilized on the methionine modified Au NCs to form a pro-drug, Au-Met-DOX. The enhanced tumor affinity and improved anti-tumor activity of this pro-drug were demonstrated. Results in this study suggest not only the prospect of non-toxic Au NCs modified with functional ligands for tumor-targeted imaging, but also confirm the promising future of Au NCs as a core for the design of pro-drug in the field of cancer therapy.

Keywords
Gold nanoclusters; Methionine; Near infrared; Target; Diagnosis; Therapy
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Multifunctional near-infrared-emitting nano-conjugates based on gold clusters for tumor imaging and therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 33, November 2012, Pages 8461–8476
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us