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A d-f heteronuclear complex for dual-mode phosphorescence and magnetic resonance imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
6924 524 2012 9 PDF Available
Title
A d-f heteronuclear complex for dual-mode phosphorescence and magnetic resonance imaging
Abstract

A d-f heteronuclear complex (Ir–Gd) by coupling an iridium(III) complex to a macrocycle-based gadolinium complex has been developed as as a dual-mode bioimaging probe for luminescence imaging and magnetic resonance imaging (MRI). The cyclometalated iridium complex showed an intense visible metal-to-ligand charge transfer (MLCT) absorption and strong yellow phosphorescent luminescence. It has specificity of staining in murine mitochondria confirmed by confocal laser scanning microscopy. The macrocycle-based gadolinium complex provides the longitudinal relaxivity of 3.36 mm−1s−1 on a 3 T system, which has been applied to MRI for liver in mice. Furthermore, the biodistribution of Ir–Gd has been investigated using inductively coupled plasma–atomic emission spectroscopy (ICP-AES) analyses. Such platform should be extended to further applications in the identification and diagnosis of liver diseases.

Keywords
d-f heteronuclear complex; Ir–Gd complex; Phosphorescence imaging; Magnetic resonance imaging
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A d-f heteronuclear complex for dual-mode phosphorescence and magnetic resonance imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 33, November 2012, Pages 8591–8599
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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