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Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent

Paper ID Volume ID Publish Year Pages File Format Full-Text
6927 524 2012 7 PDF Available
Title
Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent
Abstract

Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC50/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo.

Keywords
Main-chain imidazolium oligomer; Broad spectrum antimicrobial agent; Drug-resistant microbials; Haemocompatible; High in vivo efficacy
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Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 33, November 2012, Pages 8625–8631
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us