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Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
6949 525 2012 9 PDF Available
Title
Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging
Abstract

We demonstrate bifunctional combined Au-Fe2O3 nanoparticles (NPs) for selectively induction of apoptosis in cancer cells and real-time imaging. The as-prepared Au-Fe2O3 NPs combine the merits of both Au and γ-Fe2O3 NPs, maintaining excellent fluorescence quenching property and catalytic activity. Conjugated with αⅤβ3 integrin-targeting peptide (RGD) and fluorescein isothiocyanate (FITC)-labeled capsase-3 recognition sequence (DEVD) on the Au surface, the resulting RGD/FITC–DEVD–Au-Fe2O3 NPs bind preferentially to integrin αⅤβ3-rich human liver cancer cells (HepG2), sequentially initiate catalytic formation of hydroxyl radicals (OH) and enable the real-time monitoring ofOH-induced caspase-3-dependent apoptosis in these cancer cells. Furthermore, the catalytic activity of RGD/FITC–DEVD–Au-Fe2O3 NPs is much higher than that of individual γ-Fe2O3 NPs due to the polarization effect at the Au-Fe2O3 interface. Such bifunctional Au-Fe2O3 NPs exhibit simultaneous targeting, therapeutic and imaging functions and are therefore promising for future therapeutic applications in cancer.

Keywords
Au-Fe2O3; Combined nanoparticles; Catalytic activity; Hydroxyl radical; Apoptosis; Real-time imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 14, May 2012, Pages 3710–3718
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us