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The use of magnetic resonance cell tracking to monitor endothelial progenitor cells in a rat hindlimb ischemic model

Paper ID Volume ID Publish Year Pages File Format Full-Text
6987 527 2012 10 PDF Available
Title
The use of magnetic resonance cell tracking to monitor endothelial progenitor cells in a rat hindlimb ischemic model
Abstract

A water-soluble magnetic resonance imaging (MRI) contrast agent, Dextran mono-N-succinimidyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate-gadolinium3+ (Dex-DOTA-Gd3+), was shown to enable monitoring of the anatomical migration and the survival period of transplanted stem cells for up to 1 month. Gadolinium molecules in the cells were rapidly eliminated from the site and excreted upon cell death. Endothelial progenitor cells (EPCs) transplanted into the inguinal femoral muscle of rats migrated distally through the knee in rats after hindlimb ischemia but did not migrate in non-ischemic rats. Interestingly, the survival period of transplanted EPCs was notably prolonged in the ischemic limb, indicating that EPCs are required by the ischemic tissues and that the fate of transplanted EPCs was affected by the disease. Compared to the commonly used particle type of MRI contrast agents, the system described in this study is expected to be invaluable to help clarifying the process of stem cell transplantation therapy.

Keywords
Dextran; MRI; Progenitor cell; Transplantation
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The use of magnetic resonance cell tracking to monitor endothelial progenitor cells in a rat hindlimb ischemic model
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 8, March 2012, Pages 2439–2448
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
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Price after discount Only $4.95
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Full-text PDF Download
Online Support
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