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The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel

Paper ID Volume ID Publish Year Pages File Format Full-Text
6993 527 2012 13 PDF Available
Title
The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel
Abstract

The acidic pH in tumor tissues could be used for targeting solid tumors. In the present study, we designed a tumor-specific pH-responsive peptide H7K(R2)2, which could respond to the acidic pH in tumor tissues, and prepared H7K(R2)2-modified polymeric micelles containing paclitaxel (PTX-PM-H7K(R2)2) in order to evaluate their potential targeting of tumor cells and tumor endothelial cells and their anti-tumor activity in mice with tumor cells. PTX-PM-H7K(R2)2 was prepared by a thin-film hydration method. The in vitro release of PTX from PTX-PM-H7K(R2)2 was tested. The in vitro targeting characteristics of H7K(R2)2-modified polymeric micelles on HUVEC (human umbilical vein endothelial cells) and MCF-7 (human breast adenocarcinoma cells) were evaluated. The in vivo targeting activity of H7K(R2)2-modified polymeric micelles and the in vivo anti-tumor activity of PTX-PM-H7K(R2)2 were also investigated in MCF-7 tumor-bearing mice. The released PTX from the PTX-PM-H7K(R2)2 was not affected by the pH. The targeting activity of the H7K(R2)2-modified polymeric micelles was demonstrated by in vitro flow cytometry and confocal microscopy as well as in vivo biodistribution. PTX-PM-H7K(R2)2 produced very marked anti-tumor and anti-angiogenic activity in MCF-7 tumor-bearing mice in vivo.

Keywords
Tumor pH; pH-responsive peptide; Polymeric micelles; Targeting; anti-Tumor efficacy
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The efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing paclitaxel
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 8, March 2012, Pages 2508–2520
Authors
, , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us