fulltext.study @t Gmail

pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres

Paper ID Volume ID Publish Year Pages File Format Full-Text
6998 527 2012 10 PDF Available
Title
pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres
Abstract

In this study, we design a controlled release system based on CaF2:Ce3+/Tb3+-poly(acrylic acid) (PAA) composite microspheres, which were fabricated by filling the pH-responsive PAA inside CaF2:Ce3+/Tb3+ hollow spheres via photopolymerization route. The CaF2:Ce3+/Tb3+ hollow spheres prepared by hydrothermal route possess mesoporous structure and show strong green fluorescence from Tb3+ under UV excitation. Doxorubicin hydrochloride (DOX), a widely used anti-cancer drug, was used as a model drug to evaluate the loading and controlled release behaviors of the composite microspheres due to the good biocompatibility of the samples using MTT assay. The composite carriers provide a strongly pH-dependent drug release behavior owing to the intrinsic property of PAA and its interactions with DOX. The endocytosis process of drug-loaded microspheres was observed using confocal laser scanning microscopy (CLSM) and the in vitro cytotoxic effect against SKOV3 ovarian cancer cells of the DOX-loaded carriers was investigated. In addition, the extent of drug release could be monitored by the altering of photoluminescence (PL) intensity of CaF2:Ce3+/Tb3+. Considering the good biocompatibility, high drug loading content and pH-dependent drug release of the materials, these hybrid luminescent microspheres have potential applications in drug controlled release and disease therapy.

Keywords
Drug carrier; Poly(acrylic acid); Hollow structure; Doxorubicin; Luminescence
First Page Preview
pH-responsive drug delivery system based on luminescent CaF2:Ce3+/Tb3+-poly(acrylic acid) hybrid microspheres
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 8, March 2012, Pages 2583–2592
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us