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Long-term in vivo biodistribution and toxicity of Gd(OH)3 nanorods

Paper ID Volume ID Publish Year Pages File Format Full-Text
7019 528 2013 8 PDF Available
Title
Long-term in vivo biodistribution and toxicity of Gd(OH)3 nanorods
Abstract

The long-term retention of nanomaterials in the body is one of the biggest concerns about the safety of these materials for in vivo application. So, it is important to develop some nanomaterials which can be relatively more easily excreted. Rare earth hydroxide, that can be degraded under acidic condition in vivo, is one of the suitable candidates. Herein, Gd(OH)3 nanorods, which are considered as magnetic resonance imaging (MRI) contrast agents, have been synthesized to evaluate their excretion process and potential toxicity. The long-term in vivo biodistribution of the materials was investigated using single photon emission computed tomography (SPECT) imaging with 153Sm-doped Gd(OH)3 nanorods as probes. Biodistribution results showed that the uptake and retention of the Gd(OH)3 nanorods took place primarily in the liver, spleen and lung. Then, most of the nanorods were excreted from the bodies of mice very rapidly. Body weight data for the mice indicated that, when intravenously injected with 100 mg/kg of the nanorods, the mice survived for 150 days without any apparent adverse effects to their health. In addition, histological, hematological and biochemical analysis indicated that these nanorods have no overt toxicity.

Keywords
Gd(OH)3; Nanorods; Long-term toxicity; Biodistribution; Single photon emission computed tomography (SPECT)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 2, January 2013, Pages 508–515
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us