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Airway delivery of peptides and proteins using nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
7020 528 2013 10 PDF Available
Title
Airway delivery of peptides and proteins using nanoparticles
Abstract

Delivery of peptides and proteins via the airways is one of the most exciting potential applications of nanomedicine. These macromolecules could be used for many therapeutic applications, however due to their poor stability in physiological medium and difficulties in delivering them across biological barriers, they are very difficult to use in therapy. Nanoparticulate drug delivery systems have emerged as one of the most promising technologies to overcome these limitations, owing mainly to their proven capacity to cross biological barriers and to enter cells in high yields, thus improving delivery of macromolecules. In this review, we summarize the current advances in nanoparticle designed for transmucosal delivery of peptides and proteins. Challenges that must be overcome in order to derive clinical benefits are also discussed.

Keywords
Nanoparticles; Airway; Peptide; Protein
First Page Preview
Airway delivery of peptides and proteins using nanoparticles
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 34, Issue 2, January 2013, Pages 516–525
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering