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Europium-doped gadolinium sulfide nanoparticles as a dual-mode imaging agent for T1-weighted MR and photoluminescence imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
7036 529 2012 10 PDF Available
Title
Europium-doped gadolinium sulfide nanoparticles as a dual-mode imaging agent for T1-weighted MR and photoluminescence imaging
Abstract

We present a facile synthesis of europium-doped gadolinium sulfide (GdS:Eu3+) opto-magnetic nanoparticles (NPs) via sonochemistry. Their photoluminescence and strong paramagnetic properties enable these NPs to be utilized as an in vitro cell imaging and in vivo T1-weighted MR imaging probe. The GdS:Eu3+ NPs have a prominent longitudinal (r1) relaxivity value, which is a critical parameter for T1-weighted MR imaging. Here, we showed not only their strong positive contrast effect to blood vessels and organs of mice, but also blood half-life and biodistribution including clearance from organs, in order to assess the GdS:Eu3+ NPs as a competent nanocrystal-based T1 contrast agent. We further showed confocal images of breast cancer cells containing GdS:Eu3+ NPs to evaluate as a photoluminescence probe. Dual-mode imaging capability obtained from the GdS:Eu3+ NPs will allow target-oriented cellular imaging as well as the resulting disease-specific MR imaging.

Keywords
Europium-doped GdS nanoparticles; Positive contrast agent; MRI; Fluorescence; In vivo test
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Europium-doped gadolinium sulfide nanoparticles as a dual-mode imaging agent for T1-weighted MR and photoluminescence imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 24, August 2012, Pages 5865–5874
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us