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Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue

Paper ID Volume ID Publish Year Pages File Format Full-Text
7043 530 2012 10 PDF Available
Title
Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue
Abstract

In this study, the obtainment and characterization of decellularized rat tracheal grafts are described. The detergent-enzymatic method, already used to develop bioengineered pig and human trachea scaffolds, has been applied to rat tracheae in order to obtain airway grafts suitable to be used to improve our knowledge on the process of tissue-engineered airway transplantation and regeneration. The results demonstrated that, after 9 detergent-enzymatic cycles, almost complete decellularized tracheae, retaining the hierarchical and mechanical properties of the native tissues with strong in vivo angiogenic characteristics, could be obtained. Moreover, to improve the mechanical properties of decellularized tracheae, genipin is here considered as a naturally derived cross-linking agent. The results demonstrated that the treatment increased mechanical properties, in term of secant modulus, without neither altering the pro-angiogenic properties of decellularized airway matrices or eliciting an in vivo inflammatory response.

Keywords
Angiogenesis; Animal model; Mechanical properties; Cross-linking; Decellularized trachea; Tissue engineering
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Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 3, January 2012, Pages 780–789
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us