fulltext.study @t Gmail

Lanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents

Paper ID Volume ID Publish Year Pages File Format Full-Text
7058 530 2012 11 PDF Available
Title
Lanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents
Abstract

The design and synthesis of a combined MRI-optical probe for bio-imaging are reported. The materials studied join the properties of lanthanide (Ln3+) complexes and nanoparticles (NPs), offering an excellent solution for bimodal imaging. The hybrid SiO2@APS/DTPA:Gd:Ln (Ln = Eu3+ or Tb3+) (APS: 3-aminopropyltriethoxysilane, DTPA: diethylenetriamine pentaacetic acid) system increases the payload of the active magnetic centre (Gd3+) and introduces a Ln3+ long-life excited state (Eu3+: 0.35 ± 0.02 ms, Tb3+: 1.87 ± 0.02 ms), with resistance to photobleaching and sharp emission bands. The Eu3+ ions reside in a single low-symmetry site. Although the photoluminescence emission is not influenced by the simultaneous presence of Gd3+ and Eu3+, a moderate r1 increase and a larger enhancement of r2 are observed, particularly at high fields, due to susceptibility effects on r2. The presence of Tb3+ instead of Eu3+ further raises r1 but decreases r2. These values are constant over a wide (5–13) pH range, indicating the paramagnetic NPs stability and absence of leaching. The uptake of NPs by living cells is fast and results in an intensity increase in the T1-weighted MRI images. The optical properties of the NPs in cellular pellets are also studied, confirming their potential as bimodal imaging agents.

Keywords
Nanoparticle; Bimodal imaging; MRI contrast agents; Optical contrast agents; Photoluminescence
First Page Preview
Lanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 3, January 2012, Pages 925–935
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us