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Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria

Paper ID Volume ID Publish Year Pages File Format Full-Text
7069 533 2012 11 PDF Available
Title
Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria
Abstract

We previously reported that nanoceria can slow retinal degeneration in the tubby mouse for two weeks by multiple systemic injections. However, the long-term protection of retinal structure and function by directly deliver of nanoceria to the eye had not been explored. In this study, 172 ng of nanoceria in 1 μl saline (1 mm) were intravitreally injected into tubby P7 pups and assays were performed at P28, P49, P80 and P120. The expression of antioxidant associated genes and photoreceptor-specific genes was significantly up regulated, the mislocalization of rod and cone opsins was decreased, and retinal structure and function were protected. These findings demonstrate that nanoceria can function as catalytic antioxidants in vivo and may be broad spectrum therapeutic agents for multiple types of ocular diseases.

Keywords
Tubby mouse; Nanoceria; Antioxidant; Gene expression; Retinal degeneration; Longevity
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Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 34, December 2012, Pages 8771–8781
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us