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Tumor cells-specific targeting delivery achieved by A54 peptide functionalized polymeric micelles

Paper ID Volume ID Publish Year Pages File Format Full-Text
7078 533 2012 10 PDF Available
Title
Tumor cells-specific targeting delivery achieved by A54 peptide functionalized polymeric micelles
Abstract

The delivery of all of administrated chemotherapeutics into tumor cells is an extreme object for tumor targeting therapy to enhance the curative effect and eliminate the side effect. However, until now, the targeting delivery has only partial been realized by passive targeting, which was called “enhanced permeability and retention” effect, and only few targeting delivery system was commercialized. Here, we designed and synthesized a hepatocarcinoma-binding peptide (A54 peptide, which was identified from a phage-display random peptide library) functionalized and PEGylated stearic acid grafted chitosan (A54–PEG–CS–SA) micelles for targeting therapy of doxorubicin. The A54–PEG–CS–SA micelles presented special internalization ability into human hepatoma cells (BEL-7402) when the cells were co-incubated with normal liver cells in vitro, and high distribution ability to liver and hepatoma tissue in vivo. In vitro and in vivo anti-tumor activity results showed that A54–PEG–CS–SA micelles loading doxorubicin treatments suppressed tumor growth more effectively and reduced toxicity compared with commercial adriamycin injection.

Keywords
Stearic acid grafted chitosan; Poly(ethylene glycol); Homing peptide; Active targeting; Anti-tumor activity
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Tumor cells-specific targeting delivery achieved by A54 peptide functionalized polymeric micelles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 34, December 2012, Pages 8858–8867
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us