fulltext.study @t Gmail

Direct cell encapsulation in biodegradable and functionalizable carboxybetaine hydrogels

Paper ID Volume ID Publish Year Pages File Format Full-Text
7087 534 2012 7 PDF Available
Title
Direct cell encapsulation in biodegradable and functionalizable carboxybetaine hydrogels
Abstract

Hydrogels provide three-dimensional (3D) frames with tissue-like elasticity and high water content for tissue scaffolds. They were commonly prepared from macromers such as poly(ethylene glycol) diacrylate (PEGDA) via free radical polymerization and used to encapsulate cells. Here, we report the direct encapsulation of cells into hydrogels using a low-toxic and water-soluble monomer, carboxybetaine methacrylate (CBMA), via redox polymerization. A disulfide-containing crosslinker was added to form a biodegradable carboxybetaine (CB) hydrogel, which can be self-degraded as cells grow or degraded in an accelerating way via adding of a cysteine-contained medium NIH-3T3 cells encapsulated in the CB hydrogel formed spherical aggregates that were recovered from hydrogel erosion. Furthermore, an RGD-containing peptide was also added to improve cell adhesion on the two-dimensional (2D) hydrogel surface and promote cell proliferation in the 3D hydrogel. The non-cytotoxic and biodegradable CB hydrogel with additional cell-adhesion moieties provides an excellent 3D environment for cell growth as tissue scaffolds.

Keywords
Zwitterionic; Hydrogels; Degradation; Functionalization; Cell encapsulation
First Page Preview
Direct cell encapsulation in biodegradable and functionalizable carboxybetaine hydrogels
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 23, August 2012, Pages 5706–5712
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us