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The use of computational fluid dynamic models for the optimization of cell seeding processes ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
7099 535 2011 18 PDF Available
Title
The use of computational fluid dynamic models for the optimization of cell seeding processes ☆
Abstract

The seeding of a porous scaffold with stem cells is a fundamental step in engineering sizeable tissue constructs that are clinically viable. However, a key problem often encountered is inhomogeneous seeding of the cells particularly when the cells are delivered through the thickness of the scaffold. The objective of this study was to establish the quantitative relationships between the cell seeding efficiency and the initial vacuum pressure in a compact perfusion seeding device that uses the effect of differential pressure induced by vacuum to seed cells on a porous scaffold. A transient CFD solution of the fluid flow in the device was used to optimize the initial vacuum pressure for efficient cell seeding. Results indicate that the optimal initial vacuum pressure for homogenous cell seeding is approximately −20 kPa for the seeding device. This study presents a 3-D computational model that can be employed in designing and optimizing cell seeding techniques and corresponding technology.

Keywords
Computational fluid dynamics; Cell seeding; Bone tissue engineering; Scaffold; Stem cell
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The use of computational fluid dynamic models for the optimization of cell seeding processes ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 34, December 2011, Pages 8753–8770
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us