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In vivo biostability of polyurethane–organosilicate nanocomposites

Paper ID Volume ID Publish Year Pages File Format Full-Text
712 60 2012 11 PDF Available
Title
In vivo biostability of polyurethane–organosilicate nanocomposites
Abstract

Organically modified layered silicates were incorporated into a polyether soft-segment polyurethane to form composites of at least delaminated morphology. The primary organic modifier was a quaternary ammonium compound; however, one composite included an alternative amino undecanoic acid-modified silicate. The composites’ biostability was assessed in an in vivo ovine model over a period of 6 weeks. Attenuated total reflectance–Fourier transform infrared analysis and semi-quantitative scanning electron microscopy image rating indicate a significant enhancement of the base polyurethane biostability with the inclusion of silicate at 3 wt.%. The potential effect at 15 wt.% was confounded by probable leaching of the quaternary ammonium compound affecting the tissue response. The amino undecanoic acid composite compared favourably with the quaternary ammonium compound composite of equivalent silicate loading, and offers the promise of a more favourable tissue response.

Keywords
Nanocomposite; Polyurethane; Silicate; Organosilicate; Biostability
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In vivo biostability of polyurethane–organosilicate nanocomposites
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 6, July 2012, Pages 2243–2253
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us