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Monodisperse core–shell structured up-conversion Yb(OH)CO3@YbPO4:Er3+ hollow spheres as drug carriers

Paper ID Volume ID Publish Year Pages File Format Full-Text
7147 536 2011 13 PDF Available
Title
Monodisperse core–shell structured up-conversion Yb(OH)CO3@YbPO4:Er3+ hollow spheres as drug carriers
Abstract

In this work, we report a facile solution–phase synthesis of monodisperse core–shell structured Yb-(OH)CO3@YbPO4 hollow spheres (size around 380 nm) by utilizing the colloidal sphere of Yb(OH)CO3 as the sacrificial template via the Kirkendall effect. The Er3+ doped Yb(OH)CO3@YbPO4 core–shell hollow spheres can be prepared similarly, which exhibit strong green emission under 980 nm NIR laser excitation even after loading with drug molecules. Most importantly, the sample can be used as an effective drug delivery carrier. The biocompatibility test on L929 fibroblast cells using MTT assay reveals low cytotoxicity of the system. A typical anticancer drug, doxorubicin hydrochloride (DOX), is used for drug loading, and the release properties, cytotoxicity, uptake behavior and therapeutic effects were examined. It is found that DOX is shuttled into cell by core–shell hollow spheres carrier and released inside cells after endocytosis, and the DOX-loaded spheres exhibited greater cytotoxicity than free DOX. These results indicate that the core–shell Er3+ doped Yb(OH)CO3@YbPO4 hollow spheres have potential for drug loading and delivery into cancer cells to induce cell death.

Keywords
Core–shell; Doxorubicin; Drug delivery; Hydrothermal synthesis; Up-conversion luminescence
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Monodisperse core–shell structured up-conversion Yb(OH)CO3@YbPO4:Er3+ hollow spheres as drug carriers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 32, Issue 17, June 2011, Pages 4161–4173
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us