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Designing multilayered particulate systems for tunable drug release profiles

Paper ID Volume ID Publish Year Pages File Format Full-Text
715 60 2012 8 PDF Available
Title
Designing multilayered particulate systems for tunable drug release profiles
Abstract

Triple-layered microparticles comprising poly(d,l-lactide-co-glycolide, 50:50) (PLGA), poly(l-lactide) (PLLA) and poly(ethylene-co-vinyl acetate, 40 wt.% vinyl acetate) (EVA) were fabricated using a one-step solvent evaporation technique, with ibuprofen drug localized in the EVA core. The aim of this study was to investigate the drug release profiles of these triple-layered microparticles in comparison to double-layered (PLLA/EVA and PLGA/EVA) (shell/core) and single-layered EVA microparticles. Double- and triple-layered microparticles were shown to eliminate burst release otherwise observed for single-layered microparticles. For triple-layered microparticles, the migration of acidic PGA oligomers from the PLGA shell accelerated the degradation of the PLLA mid-layer and subsequently enhanced drug release in comparison to double-layered PLLA/EVA microparticles. Further studies showed that drug release rates can be altered by changing the layer thicknesses of the triple-layered microparticles, and through specific tailoring of layer thicknesses, a zero-order release can be achieved. This study therefore provides important mechanistic insights into how the distinctive structural attributes of triple-layered microparticles can be tuned to control the drug release profiles.

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Keywords
Degradation; Drug delivery; Multilayered microparticle; Poly(lactic acid); Poly(lactide-co-glycolide)
First Page Preview
Designing multilayered particulate systems for tunable drug release profiles
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 6, July 2012, Pages 2271–2278
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering