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Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
7152 537 2012 10 PDF Available
Title
Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors ☆
Abstract

Single walled carbon nanotubes (SWNTs) are emerging as promising delivery vehicles for cancer diagnostics and chemotherapies due to their unique properties, including, remarkable cell membrane penetrability, high drug-carrying capacities, pH-dependent therapeutic unloading, prolonged circulating times and intrinsic fluorescent, photothermal, photoacoustic and Raman properties. In this leading opinion paper, we systemically discuss and evaluate the relationship of the biological safety of SWNTs with their physicochemical properties such as their length, purity, agglomeration state, concentration and surface functionalization. Other relevant issues, including the cellular uptake mechanism, biodistribution and metabolism of SWNTs are also reviewed. The design and preparation of SWNT-based drug delivery systems (DDSs) and their pharmacokinetic, cancer targeting and therapeutic properties both in vitro and in vivo are highlighted. Future opportunities and challenges of SWNT-based DDSs are also discussed.

Keywords
Single walled carbon nanotubes (SWNTs); Doxorubicin (DOX); Polysaccharides; Drug delivery
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Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 33, Issue 6, February 2012, Pages 1689–1698
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us